1e0d: Difference between revisions

Revision as of 23:55, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1e0d.png

Template:STRUCTURE 1e0d

UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASEUDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE

Template:ABSTRACT PUBMED 9218784

About this StructureAbout this Structure

1E0D is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli., Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van Heijenoort J, Dideberg O, EMBO J. 1997 Jun 16;16(12):3416-25. PMID:9218784

Page seeded by OCA on Mon Jun 30 23:55:53 2008

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OCA

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-'''UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE'''
+===UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE===
-==Overview==
+<!--
-UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) is a cytoplasmic enzyme involved in the biosynthesis of peptidoglycan which catalyzes the addition of D-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). The crystal structure of MurD in the presence of its substrate UMA has been solved to 1.9 A resolution. Phase information was obtained from multiple anomalous dispersion using the K-shell edge of selenium in combination with multiple isomorphous replacement. The structure comprises three domains of topology each reminiscent of nucleotide-binding folds: the N- and C-terminal domains are consistent with the dinucleotide-binding fold called the Rossmann fold, and the central domain with the mononucleotide-binding fold also observed in the GTPase family. The structure reveals the binding site of the substrate UMA, and comparison with known NTP complexes allows the identification of residues interacting with ATP. The study describes the first structure of the UDP-N-acetylmuramoyl-peptide ligase family.
+The line below this paragraph, {{ABSTRACT_PUBMED_9218784}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9218784 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9218784}}
 ==About this Structure==
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 [[Category: Murd]]
 [[Category: Peptidoglycan synthesis]]
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