1dsm: Difference between revisions

Revision as of 23:33, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1dsm.png

Template:STRUCTURE 1dsm

(-)-duocarmycin SA covalently linked to duplex DNA(-)-duocarmycin SA covalently linked to duplex DNA

Template:ABSTRACT PUBMED 10903864

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

The structural basis for in situ activation of DNA alkylation by duocarmycin SA., Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ, J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:10903864

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OCA

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-'''(-)-duocarmycin SA covalently linked to duplex DNA'''
+===(-)-duocarmycin SA covalently linked to duplex DNA===
-==Overview==
+<!--
-Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.
+The line below this paragraph, {{ABSTRACT_PUBMED_10903864}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10903864 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10903864}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
 ==Reference==
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 [[Category: Duocarmycin]]
 [[Category: Minor groove binding]]
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