1dl6: Difference between revisions

Revision as of 23:14, 30 June 2008

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File:1dl6.png

Template:STRUCTURE 1dl6

SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAINSOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 11045620

About this StructureAbout this Structure

1DL6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription., Chen HT, Legault P, Glushka J, Omichinski JG, Scott RA, Protein Sci. 2000 Sep;9(9):1743-52. PMID:11045620

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-'''SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN'''
+===SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN===
-==Overview==
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-Transcription factor IIB (TFIIB) is an essential component in the formation of the transcription initiation complex in eucaryal and archaeal transcription. TFIIB interacts with a promoter complex containing the TATA-binding protein (TBP) to facilitate interaction with RNA polymerase II (RNA pol II) and the associated transcription factor IIF (TFIIF). TFIIB contains a zinc-binding motif near the N-terminus that is directly involved in the interaction with RNA pol II/TFIIF and plays a crucial role in selecting the transcription initiation site. The solution structure of the N-terminal residues 2-59 of human TFIIB was determined by multidimensional NMR spectroscopy. The structure consists of a nearly tetrahedral Zn(Cys)3(His)1 site confined by type I and "rubredoxin" turns, three antiparallel beta-strands, and disordered loops. The structure is similar to the reported zinc-ribbon motifs in several transcription-related proteins from archaea and eucarya, including Pyrococcus furiosus transcription factor B (PfTFB), human and yeast transcription factor IIS (TFIIS), and Thermococcus celer RNA polymerase II subunit M (TcRPOM). The zinc-ribbon structure of TFIIB, in conjunction with the biochemical analyses, suggests that residues on the beta-sheet are involved in the interaction with RNA pol II/TFIIF, while the zinc-binding site may increase the stability of the beta-sheet.
+The line below this paragraph, {{ABSTRACT_PUBMED_11045620}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11045620 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11045620}}
 ==About this Structure==
-DL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL6 OCA].
+DL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL6 OCA].
 ==Reference==
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 [[Category: Scott, R A.]]
 [[Category: Zinc ribbon]]
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