1dl0: Difference between revisions

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[[Image:1dl0.gif|left|200px]]
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{{STRUCTURE_1dl0|  PDB=1dl0  |  SCENE=  }}  
{{STRUCTURE_1dl0|  PDB=1dl0  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C'''
===SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C===




==Overview==
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We have isolated a family of insect-selective neurotoxins from the venom of the Australian funnel-web spider that appear to be good candidates for biopesticide engineering. These peptides, which we have named the Janus-faced atracotoxins (J-ACTXs), each contain 36 or 37 residues, with four disulfide bridges, and they show no homology to any sequences in the protein/DNA databases. The three-dimensional structure of one of these toxins reveals an extremely rare vicinal disulfide bridge that we demonstrate to be critical for insecticidal activity. We propose that J-ACTX comprises an ancestral protein fold that we refer to as the disulfide-directed beta-hairpin.
The line below this paragraph, {{ABSTRACT_PUBMED_10881200}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10881200}}


==About this Structure==
==About this Structure==
1DL0 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL0 OCA].  
1DL0 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL0 OCA].  


==Reference==
==Reference==
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[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
[[Category: Vicinal disulfide]]
[[Category: Vicinal disulfide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:58:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:13:51 2008''

Revision as of 23:13, 30 June 2008

File:1dl0.png

Template:STRUCTURE 1dl0

SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1CSOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C

Template:ABSTRACT PUBMED 10881200

About this StructureAbout this Structure

1DL0 is a Single protein structure. Full experimental information is available from OCA.

ReferenceReference

Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge., Wang X, Connor M, Smith R, Maciejewski MW, Howden ME, Nicholson GM, Christie MJ, King GF, Nat Struct Biol. 2000 Jun;7(6):505-13. PMID:10881200

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