1dff: Difference between revisions

Revision as of 22:59, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1dff.png

Template:STRUCTURE 1dff

PEPTIDE DEFORMYLASEPEPTIDE DEFORMYLASE

Template:ABSTRACT PUBMED 9374869

About this StructureAbout this Structure

1DFF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the Escherichia coli peptide deformylase., Chan MK, Gong W, Rajagopalan PT, Hao B, Tsai CM, Pei D, Biochemistry. 1997 Nov 11;36(45):13904-9. PMID:9374869

Page seeded by OCA on Mon Jun 30 22:59:48 2008

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OCA

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-'''PEPTIDE DEFORMYLASE'''
+===PEPTIDE DEFORMYLASE===
-==Overview==
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-Protein synthesis in bacteria involves the formylation and deformylation of the N-terminal methionine. As eukaryotic organisms differ in their protein biosynthetic mechanisms, peptide deformylase, the bacterial enzyme responsible for deformylation, represents a potential target for antibiotic studies. Here we report the crystallization and 2.9 A X-ray structure solution of the zinc containing Escherichia coli peptide deformylase. While the primary sequence, tertiary structure, and use of coordinated cysteine suggest that E. coli deformylase belongs to a new subfamily of metalloproteases, the environment around the metal appears to have strong geometric similarity to the active sites of the thermolysin family. This suggests a possible similarity in their hydrolytic mechanisms. Another important issue is the origin of the enzyme's specificity for N-formylated over N-acetylated substrates. Based on the structure, the specificity appears to result from hydrogen-bonding interactions which orient the substrate for cleavage, and steric factors which physically limit the size of the N-terminal carbonyl group.
+The line below this paragraph, {{ABSTRACT_PUBMED_9374869}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9374869}}
 ==About this Structure==
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 [[Category: Hydrolase]]
 [[Category: Zinc metalloprotease]]
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