1db5: Difference between revisions

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OCA

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-[[Image:1db5.gif|left|200px]]
+{{Seed}}
+[[Image:1db5.png|left|200px]]
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 {{STRUCTURE_1db5|  PDB=1db5  |  SCENE=  }}
-'''HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6'''
+===HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6===
-==Overview==
+<!--
-A lead compound obtained from a high volume human non-pancreatic secretory phospholipase A2 (hnps-PLA2) screen has been developed into a potent inhibitor using detailed structural knowledge of inhibitor binding to the enzyme active site. Four crystal structures of hnps-PLA2 complexed with a series of increasingly potent indole inhibitors were determined and used as the structural basis for both understanding this binding and providing valuable insights for further development. The application of structure-based drug design has made possible improvements in the binding of this screening lead to the enzyme by nearly three orders of magnitude. Furthermore, the optimized structure (LY311727) displayed 1,500-fold selectivity when assayed against porcine pancreatic s-PLA2.
+The line below this paragraph, {{ABSTRACT_PUBMED_7664108}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7664108 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7664108}}
 ==About this Structure==
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 [[Category: S-pla2]]
 [[Category: Structure-based drug design]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:39:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:46:18 2008''