1d48: Difference between revisions

Revision as of 22:22, 30 June 2008

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File:1d48.png

Template:STRUCTURE 1d48

STRUCTURE OF THE PURE-SPERMINE FORM OF Z-DNA (MAGNESIUM FREE) AT 1 ANGSTROM RESOLUTIONSTRUCTURE OF THE PURE-SPERMINE FORM OF Z-DNA (MAGNESIUM FREE) AT 1 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 1742278

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Structure of the pure-spermine form of Z-DNA (magnesium free) at 1-A resolution., Egli M, Williams LD, Gao Q, Rich A, Biochemistry. 1991 Dec 3;30(48):11388-402. PMID:1742278

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-'''STRUCTURE OF THE PURE-SPERMINE FORM OF Z-DNA (MAGNESIUM FREE) AT 1 ANGSTROM RESOLUTION'''
+===STRUCTURE OF THE PURE-SPERMINE FORM OF Z-DNA (MAGNESIUM FREE) AT 1 ANGSTROM RESOLUTION===
-==Overview==
+<!--
-We describe the three-dimensional X-ray structure of a complex of spermine bound to a Z-DNA duplex, [d(CGCGCG)]2, in the absence of any inorganic polyvalent cations. We have crystallized the DNA hexamer d(CGCGCG) in the exclusion of magnesium and other polyvalent ions and solved its structure at 1.0-A resolution. In the crystal of this pure-spermine form of Z-DNA, the relative orientation, position, and interactions of the DNA differ from the arrangement uniformly observed in over a dozen previously reported Z-DNA hexamers. Moreover, the conformation of the Z-DNA hexamer in this structure varies somewhat from those found in earlier structures. The DNA is compressed along the helical axis, the base pairs are shifted into the major groove, and the minor groove is more narrow. The packing of spermine-DNA complexes in crystals suggests that the molecular basis for the tendency of spermine to stabilize compact DNA structures derives from the capacity of spermine to interact simultaneously with several duplexes. This capacity is maximized by both the polymorphic nature and the length of the spermine cation. The length and flexibility of spermine and the dispersion of charge-charge, hydrogen-bonding, and hydrophobic bonding potential throughout the molecule maximize the ability of spermine to interact simultaneously with different DNA molecules.
+The line below this paragraph, {{ABSTRACT_PUBMED_1742278}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1742278 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_1742278}}
 ==About this Structure==
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 [[Category: Double helix]]
 [[Category: Z-dna]]
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