1d3x: Difference between revisions

Revision as of 22:21, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1d3x.png

Template:STRUCTURE 1d3x

INTRAMOLECULAR DNA TRIPLEX, NMR, 10 STRUCTURESINTRAMOLECULAR DNA TRIPLEX, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 9558314

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

Solution structure of an intramolecular DNA triplex linked by hexakis(ethylene glycol) units: d(AGAGAGAA-(EG)6-TTCTCTCT-(EG)6-TCTCTCTT)., Tarkoy M, Phipps AK, Schultze P, Feigon J, Biochemistry. 1998 Apr 28;37(17):5810-9. PMID:9558314

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-[[Image:1d3x.gif|left|200px]]
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 {{STRUCTURE_1d3x|  PDB=1d3x  |  SCENE=  }}
-'''INTRAMOLECULAR DNA TRIPLEX, NMR, 10 STRUCTURES'''
+===INTRAMOLECULAR DNA TRIPLEX, NMR, 10 STRUCTURES===
-==Overview==
+<!--
-A DNA molecule was designed and synthesized with three octanucleotide stretches linked by two hexakis(ethylene glycol) chains to form an intramolecular triplex in solution. The structural data obtained from a series of NMR NOESY spectra yielded interproton distances, and COSY experiments provided dihedral angle information for analysis of deoxyribose ring pucker. Using distance geometry followed by simulated annealing with restrained molecular dynamics and relaxation matrix refinement, a well-refined ensemble of conformations was calculated. Although some NOE cross-peaks involving protons of the hexakis(ethylene glycol) linker could be identified, most could not be assigned and the conformations of the linkers were not determined. The deoxyribose conformations are predominantly of the S type, except for the protonated cytosine residues in the third strand which show hybrid N and S character. Overall, the duplex part of the molecule resembles a B-DNA double helix with the third strand bound in its major groove by Hoogsteen hydrogen bonds. This structure provides a basis for comparison with triplexes containing noncanonical or nonnatural nucleotides.
+The line below this paragraph, {{ABSTRACT_PUBMED_9558314}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9558314 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9558314}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3X OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3X OCA].
 ==Reference==
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 [[Category: Rna third strand]]
 [[Category: Triplex]]
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