1d2q: Difference between revisions

Revision as of 22:13, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1d2q.png

1d2q, resolution 2.80Å ()

Structural annotation:
Resources:	UniProt : P50591

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF HUMAN TRAILCRYSTAL STRUCTURE OF HUMAN TRAIL

Template:ABSTRACT PUBMED 10485660

About this StructureAbout this Structure

1D2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity., Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH, Immunity. 1999 Aug;11(2):253-61. PMID:10485660

Page seeded by OCA on Mon Jun 30 22:13:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1d2q.gif|left|200px]]
+{{Seed}}
+[[Image:1d2q.png|left|200px]]
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 {{STRUCTURE_1d2q|  PDB=1d2q  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HUMAN TRAIL'''
+===CRYSTAL STRUCTURE OF HUMAN TRAIL===
-==Overview==
+<!--
-TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL.
+The line below this paragraph, {{ABSTRACT_PUBMED_10485660}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10485660 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10485660}}
 ==About this Structure==
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 [[Category: Cytokine]]
 [[Category: Trail]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:23:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:13:35 2008''