1cwk: Difference between revisions

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[[Image:1cwk.gif|left|200px]]
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{{STRUCTURE_1cwk|  PDB=1cwk  |  SCENE=  }}  
{{STRUCTURE_1cwk|  PDB=1cwk  |  SCENE=  }}  


'''HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN'''
===HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN===




==Overview==
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Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
The line below this paragraph, {{ABSTRACT_PUBMED_9769216}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9769216}}


==About this Structure==
==About this Structure==
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[[Category: Taylor, P.]]
[[Category: Taylor, P.]]
[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:37:53 2008''

Revision as of 21:37, 30 June 2008

File:1cwk.png

Template:STRUCTURE 1cwk

HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORINHUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN

Template:ABSTRACT PUBMED 9769216

About this StructureAbout this Structure

1CWK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216

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