1cn0: Difference between revisions

Revision as of 20:58, 30 June 2008

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File:1cn0.png

Template:STRUCTURE 1cn0

CRYSTAL STRUCTURE OF D(ACCCT)CRYSTAL STRUCTURE OF D(ACCCT)

Template:ABSTRACT PUBMED 10089350

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT)., Weil J, Min T, Yang C, Wang S, Sutherland C, Sinha N, Kang C, Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):422-9. PMID:10089350

Page seeded by OCA on Mon Jun 30 20:58:18 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''CRYSTAL STRUCTURE OF D(ACCCT)'''
+===CRYSTAL STRUCTURE OF D(ACCCT)===
-==Overview==
+<!--
-The crystal structure of d(ACCCT), solved by molecular replacement, shows a four-stranded i-motif conformation, where two parallel duplexes intercalate with one another in opposite orientations. Each duplex is stabilized by hemi-protonated C-C+ base pairing between parallel strands, and a string of water molecules bridge the cytosine N4 atoms to phosphate O atoms. This structure of d(ACCCT) shows examples of reversed Hoogsteen and Watson-Crick base pairing in both intermolecular and intramolecular manners to stabilize the tetraplex. Noticeably, the four-stranded complex is further stabilized at one end by a three-base hydrogen-bonding network, in which two adenines and a thymine form four hydrogen bonds via a reverse Hoogsteen and an asymmetric adenine-adenine base pairing. The structure of d(ACCCT) shows a similar local structure to that found in the d(TAA) part of the crystal structure of d(TAACCC) and provides further structural evidence that these base arrangements are essential for stabilizing these novel DNA super-secondary structures.
+The line below this paragraph, {{ABSTRACT_PUBMED_10089350}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10089350 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_10089350}}
 ==About this Structure==
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 [[Category: I-motif]]
 [[Category: Telomere]]
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