1ckn: Difference between revisions

Revision as of 20:52, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ckn.png

Template:STRUCTURE 1ckn

STRUCTURE OF GUANYLYLATED MRNA CAPPING ENZYME COMPLEXED WITH GTPSTRUCTURE OF GUANYLYLATED MRNA CAPPING ENZYME COMPLEXED WITH GTP

Template:ABSTRACT PUBMED 9160746

About this StructureAbout this Structure

1CKN is a Single protein structure of sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

ReferenceReference

X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes., Hakansson K, Doherty AJ, Shuman S, Wigley DB, Cell. 1997 May 16;89(4):545-53. PMID:9160746

Page seeded by OCA on Mon Jun 30 20:52:32 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''STRUCTURE OF GUANYLYLATED MRNA CAPPING ENZYME COMPLEXED WITH GTP'''
+===STRUCTURE OF GUANYLYLATED MRNA CAPPING ENZYME COMPLEXED WITH GTP===
-==Overview==
+<!--
-We have solved the crystal structure of an mRNA capping enzyme at 2.5 A resolution. The enzyme comprises two domains with a deep, but narrow, cleft between them. The two molecules in the crystallographic asymmetric unit adopt very different conformations; both contain a bound GTP, but one protein molecule is in an open conformation while the other is in a closed conformation. Only in the closed conformation is the enzyme able to bind manganese ions and undergo catalysis within the crystals to yield the covalent guanylated enzyme intermediate. These structures provide direct evidence for a mechanism that involves a significant conformational change in the enzyme during catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_9160746}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9160746 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_9160746}}
 ==About this Structure==
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 [[Category: Mrna]]
 [[Category: Nucleotidyltransferase]]
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