1cj1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
-[[Image:1cj1.gif|left|200px]]
+{{Seed}}
+[[Image:1cj1.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1cj1|  PDB=1cj1  |  SCENE=  }}
-'''GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE'''
+===GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE===
-==Overview==
+<!--
-Previous efforts in the search for molecules capable of blocking the associations between the activated tyrosine kinase growth factor receptors and the SH2 domain of Grb2 had resulted in the identification of 3-amino-Z-pTyr-Ac6c-Asn-NH2, a high-affinity and selective antagonist of this SH2 domain. In the present paper, we report the successful replacement of asparagine in this compound by a beta-amino acid mimetic, which brings us closer to our objective of identifying a Grb2-SH2 antagonist suitable for pharmacological investigations.
+The line below this paragraph, {{ABSTRACT_PUBMED_10395476}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10395476 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10395476}}
 ==About this Structure==
@@ Line 26: / Line 30: @@
 [[Category: Sh2 domain]]
 [[Category: Signal transduction]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:47:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:48:58 2008''