1ce7: Difference between revisions

Revision as of 20:37, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ce7.png

Template:STRUCTURE 1ce7

MISTLETOE LECTIN I FROM VISCUM ALBUMMISTLETOE LECTIN I FROM VISCUM ALBUM

Template:ABSTRACT PUBMED 10198229

About this StructureAbout this Structure

1CE7 is a Single protein structure of sequence from Viscum album. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of mistletoe lectin I from Viscum album., Krauspenhaar R, Eschenburg S, Perbandt M, Kornilov V, Konareva N, Mikailova I, Stoeva S, Wacker R, Maier T, Singh T, Mikhailov A, Voelter W, Betzel C, Biochem Biophys Res Commun. 1999 Apr 13;257(2):418-24. PMID:10198229

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OCA

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-'''MISTLETOE LECTIN I FROM VISCUM ALBUM'''
+===MISTLETOE LECTIN I FROM VISCUM ALBUM===
-==Overview==
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-The crystal structure of the ribosome-inactivating protein (RIP) mistletoe lectin I (ML-I) from Viscum album has been solved by molecular replacement techniques. The structure has been refined to a crystallographic R-factor of 24.5% using X-ray diffraction data to 2.8 A resolution. The heterodimeric 63-kDa protein consists of a toxic A subunit which exhibits RNA-glycosidase activity and a galactose-specific lectin B subunit. The overall protein fold is similar to that of ricin from Ricinus communis; however, unlike ricin, ML-I is already medically applied as a component of a commercially available misteltoe extract with immunostimulating potency and for the treatment of human cancer. The three-dimensional structure reported here revealed structural details of this pharmaceutically important protein. The comparison to the structure of ricin gives more insights into the functional mechanism of this protein, provides structural details for further protein engineering studies, and may lead to the development of more effective therapeutic RIPs.
+The line below this paragraph, {{ABSTRACT_PUBMED_10198229}}, adds the Publication Abstract to the page
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 [[Category: Wacker, R.]]
 [[Category: Ribosome-inactivating protein type ii]]
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