1cde: Difference between revisions

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{{STRUCTURE_1cde|  PDB=1cde  |  SCENE=  }}  
{{STRUCTURE_1cde|  PDB=1cde  |  SCENE=  }}  


'''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE'''
===STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE===




==Overview==
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The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.
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{{ABSTRACT_PUBMED_1631098}}


==About this Structure==
==About this Structure==
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[[Category: Janson, C A.]]
[[Category: Janson, C A.]]
[[Category: Kan, C C.]]
[[Category: Kan, C C.]]
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