1ccj: Difference between revisions

Revision as of 20:33, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ccj.png

Template:STRUCTURE 1ccj

CONFORMER SELECTION BY LIGAND BINDING OBSERVED WITH PROTEIN CRYSTALLOGRAPHYCONFORMER SELECTION BY LIGAND BINDING OBSERVED WITH PROTEIN CRYSTALLOGRAPHY

Template:ABSTRACT PUBMED 9514261

About this StructureAbout this Structure

1CCJ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Protein conformer selection by ligand binding observed with crystallography., Cao Y, Musah RA, Wilcox SK, Goodin DB, McRee DE, Protein Sci. 1998 Jan;7(1):72-8. PMID:9514261

Page seeded by OCA on Mon Jun 30 20:33:26 2008

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OCA

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-'''CONFORMER SELECTION BY LIGAND BINDING OBSERVED WITH PROTEIN CRYSTALLOGRAPHY'''
+===CONFORMER SELECTION BY LIGAND BINDING OBSERVED WITH PROTEIN CRYSTALLOGRAPHY===
-==Overview==
+<!--
-A large-scale movement between "closed" and "open" conformations of a protein loop was observed directly with protein crystallography by trapping individual conformers through binding of an exogenous ligand and characterization with solution kinetics. The buried indole ring of Trp191 in cytochrome c peroxidase (CCP) was displaced by exogenous ligands, causing a conformational change of loop Pro190-Asn195 and exposing Trp191 to the protein surface. Kinetic measurements are consistent with a two-step binding mechanism in which the rate-limiting step is a transition of the protein to the open state, which then binds the ligand. This large-scale conformational change of a functionally important region of CCP is independent of ligand and indicates that about 4% of the wild-type protein is in the open form in solution at any given time.
+The line below this paragraph, {{ABSTRACT_PUBMED_9514261}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9514261 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_9514261}}
 ==About this Structure==
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 [[Category: Oxidoreductase]]
 [[Category: Peroxidase]]
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