1c9q: Difference between revisions

Revision as of 20:25, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1c9q.png

Template:STRUCTURE 1c9q

AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAPAVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP

Template:ABSTRACT PUBMED 10548111

About this StructureAbout this Structure

1C9Q is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP., Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW, Nature. 1999 Oct 21;401(6755):818-22. PMID:10548111

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 {{STRUCTURE_1c9q|  PDB=1c9q  |  SCENE=  }}
-'''AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP'''
+===AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP===
-==Overview==
+<!--
-The inhibitor-of-apoptosis (IAP) family of proteins, originally identified in baculoviruses, regulate programmed cell death in a variety of organisms. IAPs inhibit specific enzymes (caspases) in the death cascade and contain one to three modules of a common 70-amino-acid motif called the BIR domain. Here we describe the nuclear magnetic resonance structure of a region encompassing the second BIR domain (BIR2) of a human IAP family member, XIAP (also called hILP or MIHA). The structure of the BIR domain consists of a three-stranded antiparallel beta-sheet and four alpha-helices and resembles a classical zinc finger. Unexpectedly, conserved amino acids within the linker region between the BIR1 and BIR2 domains were found to be critical for inhibiting caspase-3. The absence or presence of these residues may explain the differences in caspase inhibition observed for different truncated and full-length IAPs. Our data further indicate that these residues may bind to the active site and that the BIR domain may interact with an adjacent site on the enzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_10548111}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10548111 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10548111}}
 ==About this Structure==
-C9Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9Q OCA].
+C9Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9Q OCA].
 ==Reference==
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 [[Category: Inhibitor]]
 [[Category: Zinc finger]]
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