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| [[Image:1br2.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1br2| PDB=1br2 | SCENE= }} | | {{STRUCTURE_1br2| PDB=1br2 | SCENE= }} |
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| '''SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4'''
| | ===SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4=== |
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| ==Overview==
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| The crystal structures of an expressed vertebrate smooth muscle myosin motor domain (MD) and a motor domain-essential light chain (ELC) complex (MDE), both with a transition state analog (MgADP x AIF4-) in the active site, have been determined to 2.9 A and 3.5 A resolution, respectively. The MDE structure with an ATP analog (MgADP x BeFx) was also determined to 3.6 A resolution. In all three structures, a domain of the C-terminal region, the "converter," is rotated approximately 70 degrees from that in nucleotide-free skeletal subfragment 1 (S1). We have found that the MDE-BeFx and MDE-AIF4- structures are almost identical, consistent with the fact that they both bind weakly to actin. A comparison of the lever arm positions in MDE-AIF4- and in nucleotide-free skeletal S1 shows that a potential displacement of approximately 10 nm can be achieved during the power stroke. | | The line below this paragraph, {{ABSTRACT_PUBMED_9741621}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9741621 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9741621}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Trybus, K M.]] | | [[Category: Trybus, K M.]] |
| [[Category: Muscle protein]] | | [[Category: Muscle protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:51:15 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:33:45 2008'' |