1bog: Difference between revisions

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[[Image:1bog.gif|left|200px]]
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{{STRUCTURE_1bog|  PDB=1bog  |  SCENE=  }}  
{{STRUCTURE_1bog|  PDB=1bog  |  SCENE=  }}  


'''ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDE'''
===ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDE===




==Overview==
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The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum resolution of 2.6 A. The latter three peptides were identified from screening synthetic combinatorial peptide libraries. Although all peptides bind to the same antigen combining site, the nonhomologous peptides adopt different binding conformations and also form their critical contacts with different antibody residues. Only small readjustments are observed within the framework of the Fab fragment upon binding.
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{{ABSTRACT_PUBMED_9413990}}


==About this Structure==
==About this Structure==
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[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Polyspecificity]]
[[Category: Polyspecificity]]
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Revision as of 19:27, 30 June 2008

File:1bog.png

Template:STRUCTURE 1bog

ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDEANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDE

Template:ABSTRACT PUBMED 9413990

About this StructureAbout this Structure

1BOG is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity., Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W, Cell. 1997 Dec 12;91(6):811-20. PMID:9413990

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