1bk5: Difference between revisions

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-[[Image:1bk5.gif|left|200px]]
+{{Seed}}
+[[Image:1bk5.png|left|200px]]
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 {{STRUCTURE_1bk5|  PDB=1bk5  |  SCENE=  }}
-'''KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE'''
+===KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE===
-==Overview==
+<!--
-Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin alpha recognizes "classical" monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha, in the absence and presence of a monopartite NLS peptide at 2.2 A and 2.8 A resolution, respectively. The structure shows a tandem array of ten armadillo repeats, organized in a right-handed superhelix of helices. Binding of the NLS peptide occurs at two sites within a helical surface groove that is lined by conserved residues. The structure reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs.
+The line below this paragraph, {{ABSTRACT_PUBMED_9695948}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9695948 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_9695948}}
 ==About this Structure==
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 [[Category: Nls nuclear import]]
 [[Category: Protein transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:37:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:17:31 2008''