1bf8: Difference between revisions

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{{STRUCTURE_1bf8|  PDB=1bf8  |  SCENE=  }}  
{{STRUCTURE_1bf8|  PDB=1bf8  |  SCENE=  }}  


'''PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES'''
===PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES===




==Overview==
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The NMR structure of the 205-residue periplasmic chaperone FimC is presented. This protein consists of two globular domains with immunoglobulin-like folds connected by a 15-residue linker peptide. The relative orientation of the two domains is defined by hydrophobic contacts and an interdomain salt bridge. FimC mediates the assembly of type-1 pili, which are filamentous surface organelles of uropathogenic Escherichia coli strains that enable the bacteria to attach to host cell surfaces and persist in macrophages. The availability of the NMR structure of FimC provides a new basis for rational design of drugs against infections by uropathogenic bacteria.
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{{ABSTRACT_PUBMED_9783748}}


==About this Structure==
==About this Structure==
1BF8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF8 OCA].  
1BF8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF8 OCA].  


==Reference==
==Reference==
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[[Category: Pilus chaperone]]
[[Category: Pilus chaperone]]
[[Category: Type-i pili]]
[[Category: Type-i pili]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:01:22 2008''

Revision as of 19:01, 30 June 2008

File:1bf8.png

Template:STRUCTURE 1bf8

PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURESPERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9783748

About this StructureAbout this Structure

1BF8 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

ReferenceReference

NMR solution structure of the periplasmic chaperone FimC., Pellecchia M, Guntert P, Glockshuber R, Wuthrich K, Nat Struct Biol. 1998 Oct;5(10):885-90. PMID:9783748

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