1bb6: Difference between revisions

Revision as of 18:45, 30 June 2008

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File:1bb6.png

Template:STRUCTURE 1bb6

LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOTRIOSELYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOTRIOSE

Template:ABSTRACT PUBMED 10089395

About this StructureAbout this Structure

1BB6 is a Single protein structure of sequence from Oncorhynchus mykiss. Full crystallographic information is available from OCA.

ReferenceReference

Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme., Vollan VB, Hough E, Karlsen S, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):60-6. Epub 1999 Jan, 1. PMID:10089395

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-'''LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOTRIOSE'''
+===LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOTRIOSE===
-==Overview==
+<!--
-Two complexes between rainbow trout lysozyme (RBTL) and 4-methylumbelliferyl chitobioside, 4MeU-(GlcNAc)2, and chitotrioside, 4MeU-(GlcNAc)3, were produced by co-crystallization and soaking, respectively, and the crystal structures were solved at 2.0 A resolution. The results show that 4-MeU-(GlcNAc)3 binds in subsites A-D and that 4-MeU-(GlcNAc)2 binds in subsites B-D in the active-site cleft of RBTL. This agrees well with earlier crystallographic studies on the binding of oligosaccharides of chitin to RBTL, which showed that (GlcNAc)3 binds to sites B-D in RBTL and not to A-C as seen in the human and turkey egg-white lysozymes. For both complexes the 4-MeU moiety in site D has diffuse electron density and is flexible, as it is only bound to water molecules and not to the protein. Since no electron density was observed in site E, the solved structures give views of nonproductive enzyme-substrate complexes.
+The line below this paragraph, {{ABSTRACT_PUBMED_10089395}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10089395 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_10089395}}
 ==About this Structure==
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 [[Category: N-acetyl-muramidase]]
 [[Category: Umbelliferone glycoside]]
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