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| {{STRUCTURE_1b9b| PDB=1b9b | SCENE= }} | | {{STRUCTURE_1b9b| PDB=1b9b | SCENE= }} |
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| '''TRIOSEPHOSPHATE ISOMERASE OF THERMOTOGA MARITIMA'''
| | ===TRIOSEPHOSPHATE ISOMERASE OF THERMOTOGA MARITIMA=== |
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| ==Overview==
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| The molecular mechanisms that evolution has been employing to adapt to environmental temperatures are poorly understood. To gain some further insight into this subject we solved the crystal structure of triosephosphate isomerase (TIM) from the hyperthermophilic bacterium Thermotoga maritima (TmTIM). The enzyme is a tetramer, assembled as a dimer of dimers, suggesting that the tetrameric wild-type phosphoglycerate kinase PGK-TIM fusion protein consists of a core of two TIM dimers covalently linked to 4 PGK units. The crystal structure of TmTIM represents the most thermostable TIM presently known in its 3D-structure. It adds to a series of nine known TIM structures from a wide variety of organisms, spanning the range from psychrophiles to hyperthermophiles. Several properties believed to be involved in the adaptation to different temperatures were calculated and compared for all ten structures. No sequence preferences, correlated with thermal stability, were apparent from the amino acid composition or from the analysis of the loops and secondary structure elements of the ten TIMs. A common feature for both psychrophilic and T. maritima TIM is the large number of salt bridges compared with the number found in mesophilic TIMs. In the two thermophilic TIMs, the highest amount of accessible hydrophobic surface is buried during the folding and assembly process. | | The line below this paragraph, {{ABSTRACT_PUBMED_10591103}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10591103 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10591103}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Thermophilic]] | | [[Category: Thermophilic]] |
| [[Category: Thermotoga maritima]] | | [[Category: Thermotoga maritima]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:14:09 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:37:09 2008'' |