1b6a: Difference between revisions

Revision as of 18:21, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1b6a.png

Template:STRUCTURE 1b6a

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470

Template:ABSTRACT PUBMED 9812898

About this StructureAbout this Structure

1B6A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of human methionine aminopeptidase-2 complexed with fumagillin., Liu S, Widom J, Kemp CW, Crews CM, Clardy J, Science. 1998 Nov 13;282(5392):1324-7. PMID:9812898

Page seeded by OCA on Mon Jun 30 18:21:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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+===HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470===
-==Overview==
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-The fungal metabolite fumagillin suppresses the formation of new blood vessels, and a fumagillin analog is currently in clinical trials as an anticancer agent. The molecular target of fumagillin is methionine aminopeptidase-2 (MetAP-2). A 1.8 A resolution crystal structure of free and inhibited human MetAP-2 shows a covalent bond formed between a reactive epoxide of fumagillin and histidine-231 in the active site of MetAP-2. Extensive hydrophobic and water-mediated polar interactions with other parts of fumagillin provide additional affinity. Fumagillin-based drugs inhibit MetAP-2 but not MetAP-1, and the three-dimensional structure also indicates the likely determinants of this specificity. The structural basis for fumagillin's potency and specificity forms the starting point for structure-based drug design.
+The line below this paragraph, {{ABSTRACT_PUBMED_9812898}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Aminopeptidase]]
 [[Category: Angiogenesis inhibitor]]
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