1axi: Difference between revisions

Revision as of 17:48, 30 June 2008

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File:1axi.png

Template:STRUCTURE 1axi

STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACESTRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE

Template:ABSTRACT PUBMED 9353194

About this StructureAbout this Structure

1AXI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural plasticity in a remodeled protein-protein interface., Atwell S, Ultsch M, De Vos AM, Wells JA, Science. 1997 Nov 7;278(5340):1125-8. PMID:9353194

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OCA

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-'''STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE'''
+===STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE===
-==Overview==
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-Remodeling of the interface between human growth hormone (hGH) and the extracellular domain of its receptor was studied by deleting a critical tryptophan residue (at position 104) in the receptor, creating a large cavity, and selecting a pentamutant of hGH by phage display that fills the cavity and largely restores binding affinity. A 2.1 A resolution x-ray structure of the mutant complex showed that the receptor cavity was filled by selected hydrophobic mutations of hGH. Large structural rearrangements occurred in the interface at sites that were distant from the mutations. Such plasticity may be a means for protein-protein interfaces to adapt to mutations as they coevolve.
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 ==About this Structure==
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 [[Category: Vos, A M.De.]]
 [[Category: Wells, J A.]]
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