1axc: Difference between revisions

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OCA

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-[[Image:1axc.gif|left|200px]]
+{{Seed}}
+[[Image:1axc.png|left|200px]]
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 {{STRUCTURE_1axc|  PDB=1axc  |  SCENE=  }}
-'''HUMAN PCNA'''
+===HUMAN PCNA===
-==Overview==
+<!--
-The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21 binds to PCNA in a 1:1 stoichiometry with an extensive array of interactions that include the formation of a beta sheet with the interdomain connector loop of PCNA. An intact trimeric ring is maintained in the structure of the p21-PCNA complex, with a central hole available for DNA interaction. The ability of p21 to inhibit the action of PCNA is therefore likely to be due to its masking of elements on PCNA that are required for the binding of other components of the polymerase assembly.
+The line below this paragraph, {{ABSTRACT_PUBMED_8861913}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8861913 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8861913}}
 ==About this Structure==
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 [[Category: Replication]]
 [[Category: Waf1]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:48:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:47:33 2008''