1ak7: Difference between revisions

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-[[Image:1ak7.gif|left|200px]]
+{{Seed}}
+[[Image:1ak7.png|left|200px]]
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 {{STRUCTURE_1ak7|  PDB=1ak7  |  SCENE=  }}
-'''DESTRIN, NMR, 20 STRUCTURES'''
+===DESTRIN, NMR, 20 STRUCTURES===
-==Overview==
+<!--
-Destrin is an isoprotein of cofilin that regulates actin cytoskeleton in various eukaryotes. We determined the tertiary structure of destrin by triple-resonance multidimensional nuclear magnetic resonance. In spite of there being no significant amino acid sequence homology, we found that the folding of destrin was strikingly similar to that of repeated segments in the gelsolin family, which resulted in a new protein fold group. Sequential dissimilarity of the actin-binding helix of destrin to that of gelsolin explains the Ca2+-independent actin-binding of destrin. Possible mechanisms of phosphorylation-sensitive phosphoinositide-competitive actin binding, of pH-dependent filament severing, and of nuclear translocation with actin in response to stresses, are discussed on the basis of the tertiary structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_8674111}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8674111 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8674111}}
 ==About this Structure==
-AK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK7 OCA].
+AK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK7 OCA].
 ==Reference==
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 [[Category: Yahara, I.]]
 [[Category: Actin depolymerization factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:22:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:01:25 2008''