1ain: Difference between revisions

Revision as of 16:55, 30 June 2008

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File:1ain.png

Template:STRUCTURE 1ain

CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTIONCRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8453382

About this StructureAbout this Structure

1AIN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of human annexin I at 2.5 A resolution., Weng X, Luecke H, Song IS, Kang DS, Kim SH, Huber R, Protein Sci. 1993 Mar;2(3):448-58. PMID:8453382

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-'''CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION'''
+===CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION===
-==Overview==
+<!--
-cDNA coding for N-terminally truncated human annexin I, a member of the family of Ca(2+)-dependent phospholipid binding proteins, has been cloned and expressed in Escherichia coli. The expressed protein is biologically active, and has been purified and crystallized in space group P2(1)2(1)2(1) with cell dimensions a = 139.36 A, b = 67.50 A, and c = 42.11 A. The crystal structure has been determined by molecular replacement at 3.0 A resolution using the annexin V core structure as the search model. The average backbone deviation between these two structures is 2.34 A. The structure has been refined to an R-factor of 17.7% at 2.5 A resolution. Six calcium sites have been identified in the annexin I structure. Each is located in the loop region of the helix-loop-helix motif. Two of the six calcium sites in annexin I are not occupied in the annexin V structure. The superpositions of the corresponding loop regions in the four domains show that the calcium binding loops in annexin I can be divided into two classes: type II and type III. Both classes are different from the well-known EF-hand motif (type I).
+The line below this paragraph, {{ABSTRACT_PUBMED_8453382}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8453382 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8453382}}
 ==About this Structure==
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 [[Category: Kim, S H.]]
 [[Category: Calcium/phospholipid binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:19:08 2008''
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