1abo: Difference between revisions

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-[[Image:1abo.jpg|left|200px]]
+{{Seed}}
+[[Image:1abo.png|left|200px]]
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 {{STRUCTURE_1abo|  PDB=1abo  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE'''
+===CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE===
-==Overview==
+<!--
-Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3.
+The line below this paragraph, {{ABSTRACT_PUBMED_7664083}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7664083 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7664083}}
 ==About this Structure==
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 [[Category: Proto-oncogene]]
 [[Category: Sh3 domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:04:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:32:29 2008''