1a76: Difference between revisions

Revision as of 16:17, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1a76.png

Template:STRUCTURE 1a76

FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHIIFLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII

Template:ABSTRACT PUBMED 9699635

About this StructureAbout this Structure

1A76 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of flap endonuclease-1 from Methanococcus jannaschii., Hwang KY, Baek K, Kim HY, Cho Y, Nat Struct Biol. 1998 Aug;5(8):707-13. PMID:9699635

Page seeded by OCA on Mon Jun 30 16:17:24 2008

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OCA

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-'''FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII'''
+===FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII===
-==Overview==
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-Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii, determined at 2.0 A resolution, reveals an active site with two metal ions residing on top of a deep cleft where several conserved acidic residues are clustered. Near the active site, a long flexible loop comprised of many basic and aromatic residues forms a hole large enough to accommodate the DNA substrate. Deletion mutations in this loop significantly decreased the nuclease activity and specificity of FEN-1, suggesting that the loop is critical for recognition and cleavage of the junction between single and double-stranded regions of flap DNA.
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+{{ABSTRACT_PUBMED_9699635}}
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