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| [[Image:1a1z.gif|left|200px]] | | {{Seed}} |
| | [[Image:1a1z.png|left|200px]] |
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| {{STRUCTURE_1a1z| PDB=1a1z | SCENE= }} | | {{STRUCTURE_1a1z| PDB=1a1z | SCENE= }} |
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| '''FADD DEATH EFFECTOR DOMAIN, F25G MUTANT, NMR MINIMIZED AVERAGE STRUCTURE'''
| | ===FADD DEATH EFFECTOR DOMAIN, F25G MUTANT, NMR MINIMIZED AVERAGE STRUCTURE=== |
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| ==Overview==
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| When activated, membrane-bound receptors for Fas and tumour-necrosis factor initiate programmed cell death by recruiting the death domain of the adaptor protein FADD to the membrane. FADD then activates caspase 8 (also known as FLICE or MACH) through an interaction between the death-effector domains of FADD and caspase 8. This ultimately leads to the apoptotic response. Death-effector domains and homologous protein modules known as caspase-recruitment domains have been found in several proteins and are important regulators of caspase (FLICE) activity and of apoptosis. Here we describe the solution structure of a soluble, biologically active mutant of the FADD death-effector domain. The structure consists of six antiparallel, amphipathic alpha-helices and resembles the overall fold of the death domains of Fas and p75. Despite this structural similarity, mutations that inhibit protein-protein interactions involving the Fas death domain have no effect when introduced into the FADD death-effector domain. Instead, a hydrophobic region of the FADD death-effector domain that is not present in the death domains is vital for binding to FLICE and for apoptotic activity.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9582077}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9582077 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9582077}} |
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| ==About this Structure== | | ==About this Structure== |
| 1A1Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1Z OCA]. | | 1A1Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1Z OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Apoptosis]] | | [[Category: Apoptosis]] |
| [[Category: Death effector domain]] | | [[Category: Death effector domain]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:41:21 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:49:09 2008'' |