137d: Difference between revisions

Revision as of 15:28, 30 June 2008

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File:137d.png

Template:STRUCTURE 137d

A-DNA DECAMER D(GCGGGCCCGC)-ORTHORHOMBIC CRYSTAL FORMA-DNA DECAMER D(GCGGGCCCGC)-ORTHORHOMBIC CRYSTAL FORM

Template:ABSTRACT PUBMED 8218212

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Evidence for crystal environment dominating base sequence effects on DNA conformation: crystal structures of the orthorhombic and hexagonal polymorphs of the A-DNA decamer d(GCGGGCCCGC) and comparison with their isomorphous crystal structures., Ramakrishnan B, Sundaralingam M, Biochemistry. 1993 Oct 26;32(42):11458-68. PMID:8218212

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-[[Image:137d.gif|left|200px]]
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 {{STRUCTURE_137d|  PDB=137d  |  SCENE=  }}
-'''A-DNA DECAMER D(GCGGGCCCGC)-ORTHORHOMBIC CRYSTAL FORM'''
+===A-DNA DECAMER D(GCGGGCCCGC)-ORTHORHOMBIC CRYSTAL FORM===
-==Overview==
+<!--
-We have determined the structure of the A-DNA decamer d(GCGGGCCCGC) in two crystal forms, orthorhombic and hexagonal, at 1.7- and 1.8-A resolution, respectively. In the orthorhombic form, the fifth guanine residue has nearly trans-trans conformations for the alpha-gamma backbone torsions, as in the isomorphous orthorhombic structure d(CCCGGCCGGG) [Ramakrishnan, B., &amp; Sundaralingam, M. (1993) J. Mol. Biol. 231, 431-444]. However, in the hexagonal form, the eighth cytosine residue adopts the trans-trans conformations for the backbone alpha-gamma torsions, as in the isomorphous hexagonal structure d(ACCGGCCGGT) [Frederick, C. A., Quigley, G. J., Teng, M.-K., Coll, M., van der Marel, G. A., van Boom, J. H., Rich, A., &amp; Wang, A. H.-J. (1989) Eur. J. Biochem. 181, 295-307]. Even though the average helix and base-pair parameters are nearly the same in the two polymorphous crystal forms having the same sequence, many of the base-dependent local helix parameters are quite different. However, in the isomorphous crystal forms, in spite of the differing base sequences, the local helix and base-pair parameters of the duplexes are nearly the same. This indicates that, in crystals, the local conformation of a DNA structure is affected severely by the crystal packing environment rather than by the base sequence.
+The line below this paragraph, {{ABSTRACT_PUBMED_8218212}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8218212 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8218212}}
 ==About this Structure==
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 [[Category: A-dna]]
 [[Category: Double helix]]
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