104d: Difference between revisions

Revision as of 15:07, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:104d.png

Template:STRUCTURE 104d

DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS INDNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN

Template:ABSTRACT PUBMED 7857947

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

DNA duplexes flanked by hybrid duplexes: the solution structure of chimeric junctions in [r(cgcg)d(TATACGCG)]2., Zhu L, Salazar M, Reid BR, Biochemistry. 1995 Feb 21;34(7):2372-80. PMID:7857947

Page seeded by OCA on Mon Jun 30 15:07:05 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:104d.jpg|left|200px]]
+{{Seed}}
+[[Image:104d.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_104d|  PDB=104d  |  SCENE=  }}
-'''DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN'''
+===DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN===
-==Overview==
+<!--
-Hybrid duplexes and chimeric duplexes containing hybrid segments linked to pure DNA (or pure RNA) segments are involved in transcription and replication, as well as reverse transcription. A complete understanding of the mechanism of these processes requires detailed information on such duplexes and the junctions between duplexes of differing structure. Using two-dimensional NMR, restrained molecular dynamics and mechanics, and back-calculation refinement against the nuclear Overhauser effect spectra at various mixing times, we have determined the solution structure of the chimeric duplex [r(cgcg)d-(TATACGCG)]2 containing a pure DNA segment in the center of a hybrid duplex. The solution structure differs from the previously determined X-ray structure of the analogous duplex [r(gcg)d(TATACGC)]2, which was found to be A-form throughout [Wang, A.H.-J., et al. (1982) Nature 299, 601-604]. The basic features of the solution structure are (a) the RNA residues are all A-form with C3'-endo sugar conformations, (b) the central DNA segment is B-form, (c) the transition from A-form RNA sugar conformations to B-form DNA sugar conformations involves only the dT5 base step, and (d) although the sugar conformations of the DNA residues A6-G12 are closer to B-form, the basic helical properties of the peripheral RNA.DNA hybrid segments are closer to typical A-form than to B-form.
+The line below this paragraph, {{ABSTRACT_PUBMED_7857947}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7857947 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7857947}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=104D OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=104D OCA].
 ==Reference==
@@ Line 29: / Line 33: @@
 [[Category: Nmr]]
 [[Category: Rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:24:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:07:05 2008''