2ffl: Difference between revisions

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[[Image:2ffl.gif|left|200px]]
[[Image:2ffl.png|left|200px]]


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==Overview==
{{ABSTRACT_16410517}}
The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length. In the crystal structure of an intact Dicer enzyme, the PAZ domain, a module that binds the end of dsRNA, is separated from the two catalytic ribonuclease III (RNase III) domains by a flat, positively charged surface. The 65 angstrom distance between the PAZ and RNase III domains matches the length spanned by 25 base pairs of RNA. Thus, Dicer itself is a molecular ruler that recognizes dsRNA and cleaves a specified distance from the helical end.


==About this Structure==
==About this Structure==
2FFL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFL OCA].  
2FFL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFL OCA].  
==Reference==
Structural basis for double-stranded RNA processing by Dicer., Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA, Science. 2006 Jan 13;311(5758):195-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16410517 16410517]
[[Category: Giardia intestinalis]]
[[Category: Giardia intestinalis]]
[[Category: Ribonuclease III]]
[[Category: Ribonuclease III]]
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[[Category: Rna interference]]
[[Category: Rna interference]]
[[Category: Rnai]]
[[Category: Rnai]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:50:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:16:26 2008''

Revision as of 18:16, 26 June 2008

File:2ffl.png

Template:STRUCTURE 2ffl

Crystal Structure of Dicer from Giardia intestinalis


Template:ABSTRACT 16410517

About this StructureAbout this Structure

2FFL is a Single protein structure of sequence from Giardia intestinalis. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:16:26 2008

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