1owt: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1owt.jpg|left|200px]]
+[[Image:1owt.png|left|200px]]
 <!--
@@ Line 12: / Line 12: @@
-==Overview==
+{{ABSTRACT_12611883}}
-A major source of free radical production in the brain derives from copper. To prevent metal-mediated oxidative stress, cells have evolved complex metal transport systems. The Alzheimer's disease amyloid precursor protein (APP) is a major regulator of neuronal copper homeostasis. APP knockout mice have elevated copper levels in the cerebral cortex, whereas APP-overexpressing transgenic mice have reduced brain copper levels. Importantly, copper binding to APP can greatly reduce amyloid beta production in vitro. To understand this interaction at the molecular level we solved the structure of the APP copper binding domain (CuBD) and found that it contains a novel copper binding site that favors Cu(I) coordination. The surface location of this site, structural homology of CuBD to copper chaperones, and the role of APP in neuronal copper homeostasis are consistent with the CuBD acting as a neuronal metallotransporter.
 ==Disease==
@@ Line 20: / Line 19: @@
 ==About this Structure==
 OWT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1OWT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWT OCA].
-==Reference==
-Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis., Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R, J Biol Chem. 2003 May 9;278(19):17401-7. Epub 2003 Feb 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12611883 12611883]
 [[Category: Amyloid-beta Precursor Protein]]
 [[Category: Homo sapiens]]
@@ Line 41: / Line 37: @@
 [[Category: Williamson, N A.]]
 [[Category: Beta-alpha-beta-beta]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:22:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:48:12 2008''