1krv: Difference between revisions

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[[Image:1krv.gif|left|200px]]
[[Image:1krv.png|left|200px]]


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==Overview==
{{ABSTRACT_11937062}}
The galactoside acetyltransferase (thiogalactoside transacetylase) of Escherichia coli (GAT, LacA, EC 2.3.1.18) is a gene product of the classical lac operon. GAT may assist cellular detoxification by acetylating nonmetabolizable pyranosides, thereby preventing their reentry into the cell. The structure of GAT has been solved in binary complexes with acetyl-CoA or CoA and in ternary complexes with CoA and the nonphysiological acceptor substrates isopropyl beta-D-thiogalactoside (IPTG) or p-nitrophenyl beta-D-galactopyranoside (PNPbetaGal). A hydrophobic cleft that binds the thioisopropyl and p-nitrophenyl aglycones of IPTG and PNPbetaGal may discriminate against substrates with hydrophilic substituents at this position, such as lactose, or inducers of the lac operon. An extended loop projecting from the left-handed parallel beta helix domain contributes His115, which is in position to facilitate attack of the C6-hydroxyl group of the substrate on the thioester.


==About this Structure==
==About this Structure==
1KRV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1KRV with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb39_1.html lac Repressor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KRV OCA].  
1KRV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1KRV with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb39_1.html lac Repressor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KRV OCA].  
==Reference==
Structure of the lac operon galactoside acetyltransferase., Wang XG, Olsen LR, Roderick SL, Structure. 2002 Apr;10(4):581-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937062 11937062]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Galactoside O-acetyltransferase]]
[[Category: Galactoside O-acetyltransferase]]
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[[Category: Wang, X G.]]
[[Category: Wang, X G.]]
[[Category: Left-handed parallel beta helix]]
[[Category: Left-handed parallel beta helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:05:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:38:49 2008''

Revision as of 17:38, 26 June 2008

File:1krv.png

Template:STRUCTURE 1krv

Galactoside Acetyltransferase in Complex with CoA and PNP-beta-Gal


Template:ABSTRACT 11937062

About this StructureAbout this Structure

1KRV is a Single protein structure of sequence from Escherichia coli. The following page contains interesting information on the relation of 1KRV with [lac Repressor]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:38:49 2008

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