1k4c: Difference between revisions

Revision as of 17:37, 26 June 2008

Ligands:

, ,

Structural annotation:
Resources:	CATH : 1K4Ca02, 1K4Ca01, 1K4Cb02, 1K4Cb01, 1K4Cc00 InterPro : Ipr013099, Ipr003091 Pfam : PF07885 SCOP : d1k4ca2, d1k4ca1, d1k4cb2, d1k4cb1, d1k4cc_

Evolutionary conservation:

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Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

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Potassium Channel KcsA-Fab complex in high concentration of K+

Template:ABSTRACT 11689936

About this StructureAbout this Structure

1K4C is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. The following page contains interesting information on the relation of 1K4C with [Potassium Channels]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:37:05 2008

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OCA

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-[[Image:1k4c.gif|left|200px]]
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-==Overview==
+{{ABSTRACT_11689936}}
-Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel in complex with a monoclonal Fab antibody fragment at 2.0 A resolution. Here we show how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water molecules in a cavity near its intracellular entryway. Carbonyl oxygen atoms within the selectivity filter form a very similar square antiprism around each K+ binding site, as if to mimic the waters of hydration. The selectivity filter changes its ion coordination structure in low K+ solutions. This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating.
 ==About this Structure==
 K4C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. The following page contains interesting information on the relation of 1K4C with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb38_1.html Potassium Channels]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4C OCA].
-==Reference==
-Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution., Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R, Nature. 2001 Nov 1;414(6859):43-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11689936 11689936]
 [[Category: Mus musculus]]
 [[Category: Potassium Channels]]
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 [[Category: K channel]]
 [[Category: Protein-antibody fab complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:17:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:37:05 2008''

1k4c: Difference between revisions

Revision as of 17:37, 26 June 2008

About this StructureAbout this Structure

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