1hcq: Difference between revisions

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[[Image:1hcq.gif|left|200px]]
[[Image:1hcq.png|left|200px]]


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==Overview==
{{ABSTRACT_8221895}}
The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific complex between the DNA-binding domain from the estrogen receptor and DNA. The protein binds as a symmetrical dimer to its palindromic binding site consisting of two 6 bp consensus half sites with three intervening base pairs. This structure reveals how the protein recognizes its own half site sequence rather than that of the related glucocorticoid receptor, which differs by only two base pairs. Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family.


==About this Structure==
==About this Structure==
1HCQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCQ OCA].  
1HCQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCQ OCA].  
==Reference==
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements., Schwabe JW, Chapman L, Finch JT, Rhodes D, Cell. 1993 Nov 5;75(3):567-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8221895 8221895]
[[Category: Estrogen Receptor]]
[[Category: Estrogen Receptor]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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Revision as of 17:27, 26 June 2008

File:1hcq.png

Template:STRUCTURE 1hcq

THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS


Template:ABSTRACT 8221895

About this StructureAbout this Structure

1HCQ is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1HCQ with [Estrogen Receptor]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:27:48 2008

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