1dkg: Difference between revisions

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[[Image:1dkg.jpg|left|200px]]
[[Image:1dkg.png|left|200px]]


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==Overview==
{{ABSTRACT_9103205}}
The crystal structure of the adenine nucleotide exchange factor GrpE in complex with the adenosine triphosphatase (ATPase) domain of Escherichia coli DnaK [heat shock protein 70 (Hsp70)] was determined at 2.8 angstrom resolution. A dimer of GrpE binds asymmetrically to a single molecule of DnaK. The structure of the nucleotide-free ATPase domain in complex with GrpE resembles closely that of the nucleotide-bound mammalian Hsp70 homolog, except for an outward rotation of one of the subdomains of the protein. This conformational change is not consistent with tight nucleotide binding. Two long alpha helices extend away from the GrpE dimer and suggest a role for GrpE in peptide release from DnaK.


==About this Structure==
==About this Structure==
1DKG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1DKG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb32_1.html Chaperones]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKG OCA].  
1DKG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1DKG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb32_1.html Chaperones]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKG OCA].  
==Reference==
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK., Harrison CJ, Hayer-Hartl M, Di Liberto M, Hartl F, Kuriyan J, Science. 1997 Apr 18;276(5311):431-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9103205 9103205]
[[Category: Chaperones]]
[[Category: Chaperones]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Molecular chaperone]]
[[Category: Molecular chaperone]]
[[Category: Nucleotide exchange factor]]
[[Category: Nucleotide exchange factor]]
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Revision as of 17:10, 26 June 2008

File:1dkg.png

Template:STRUCTURE 1dkg

CRYSTAL STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR GRPE BOUND TO THE ATPASE DOMAIN OF THE MOLECULAR CHAPERONE DNAK


Template:ABSTRACT 9103205

About this StructureAbout this Structure

1DKG is a Protein complex structure of sequences from Escherichia coli. The following page contains interesting information on the relation of 1DKG with [Chaperones]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:10:52 2008

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