2r6d: Difference between revisions
New page: '''Unreleased structure''' The entry 2r6d is ON HOLD until sometime in the future Authors: Bailey, S., Eliason, W.K., Steitz, T.A. Description: Crystal Form B1 ''Page seeded by [http... |
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{{STRUCTURE_2r6d| PDB=2r6d | SCENE= }} | |||
'''Crystal Form B1''' | |||
==Overview== | |||
The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site. | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 | ==About this Structure== | ||
2R6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6D OCA]. | |||
==Reference== | |||
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17947583 17947583] | |||
[[Category: Geobacillus stearothermophilus]] | |||
[[Category: Single protein]] | |||
[[Category: Bailey, S.]] | |||
[[Category: Eliason, W K.]] | |||
[[Category: Steitz, T A.]] | |||
[[Category: Helicase]] | |||
[[Category: Hexameric]] | |||
[[Category: Replication dnab]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:44:39 2008'' | |||
Revision as of 10:44, 11 June 2008
Crystal Form B1
OverviewOverview
The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.
About this StructureAbout this Structure
2R6D is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:17947583 Page seeded by OCA on Wed Jun 11 10:44:39 2008