2g1r: Difference between revisions
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[[Category: Mcconnella, P.]] | [[Category: Mcconnella, P.]] | ||
[[Category: Zhanga, E.]] | [[Category: Zhanga, E.]] | ||
[[Category: Hydrolase]] | |||
[[Category: Protein-ligand complex]] | [[Category: Protein-ligand complex]] | ||
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Revision as of 10:01, 5 June 2008
Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring
OverviewOverview
A systematic investigation of the S3 sub-pocket activity requirements was conducted. It was observed that linear and sterically small side chain substituents are preferred in the S3 sub-pocket for optimal renin inhibition. Polar groups in the S3-sub-pocket were not well tolerated and caused a reduction in renin inhibitory activity. Further, compounds with clog P's < or = 3 demonstrated a dramatic reduction in CYP3A4 inhibitory activity.
DiseaseDisease
Known disease associated with this structure: Renal tubular dysgenesis OMIM:[179820], Hyperproreninemia OMIM:[179820]
About this StructureAbout this Structure
2G1R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Ketopiperazine-based renin inhibitors: optimization of the "C" ring., Holsworth DD, Cai C, Cheng XM, Cody WL, Downing DM, Erasga N, Lee C, Powell NA, Edmunds JJ, Stier M, Jalaie M, Zhang E, McConnell P, Ryan MJ, Bryant J, Li T, Kasani A, Hall E, Subedi R, Rahim M, Maiti S, Bioorg Med Chem Lett. 2006 May 1;16(9):2500-4. Epub 2006 Feb 15. PMID:16480874 Page seeded by OCA on Thu Jun 5 10:01:52 2008