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| You can take a close look at the peptide in HLA-B*3508 in the PDB entry [[2h6p]]. The backbone of the entire protein is shown here on the left. The protein chain forms a cylindrical can (shown in blue), with one portion of the strand threading straight through the middle (shown in green). The chromophore is found right in the middle of the can, totally shielded from the surrounding environment. This shielding is essential for the fluorescence. The jostling water molecules would normally rob the chromophore of its energy once it absorbs a photon. But inside the protein, it is protected, releasing the energy instead as a slightly less energetic photon of light. The chromophore (shown in the close-up on the right) forms spontaneously from three amino acids in the protein chain: a glycine, a tyrosine and a threonine (or serine). Notice how the glycine and the threonine have formed a new bond, creating an unusual five-membered ring. | | You can take a close look at the peptide in HLA-B*3508 in the PDB entry [[2h6p]]. This is made up of a heavy chain and the immunoglobulin like domain, <scene name='Sandbox_3/Beta2m/1'>beta2m</scene>, |
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| == TCR == | | == TCR == |
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| ou can take a close look at the peptide in HLA-B*3508 in the PDB entry [[2h6p]]. The backbone of the entire protein is shown here on the left. The protein chain forms a cylindrical can (shown in blue), with one portion of the strand threading straight through the middle (shown in green). The chromophore is found right in the middle of the can, totally shielded from the surrounding environment. This shielding is essential for the fluorescence. The jostling water molecules would normally rob the chromophore of its energy once it absorbs a photon. But inside the protein, it is protected, releasing the energy instead as a slightly less energetic photon of light. The chromophore (shown in the close-up on the right) forms spontaneously from three amino acids in the protein chain: a glycine, a tyrosine and a threoni
| | The TCR is made up of an alpha and beta chain. |
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Revision as of 16:55, 31 May 2008
MHC Class IMHC Class I
Exploring the Structure
You can take a close look at the peptide in HLA-B*3508 in the PDB entry 2h6p. This is made up of a heavy chain and the immunoglobulin like domain, ,
TCRTCR
The TCR is made up of an alpha and beta chain.
TCR_PMHCTCR_PMHC