Sandbox 8: Difference between revisions
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This model contains <scene name=' | This model contains <scene name='Sandbox_8/Ligand_kys/1'>the ruthenium ligant (KYS).</scene>. | ||
Revision as of 17:45, 23 May 2008
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This is a T7-tagged full-length streptavidin complexed with ruthenium ligand.
Guided by the X-ray structure of an S-selective artificial transfer hydrogenase, designed evolution was used to optimize the selectivity of hybrid catalysts. Fine-tuning of the second coordination sphere of the ruthenium center (see picture, orange sphere) by introduction of two point mutations allowed the identification of selective artificial transfer hydrogenases for the reduction of dialkyl ketones.
This model contains .