6pfk: Difference between revisions

Revision as of 22:42, 4 May 2008

PHOSPHOFRUCTOKINASE, INHIBITED T-STATE

OverviewOverview

Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.

About this StructureAbout this Structure

6PFK is a Single protein structure of sequence from Geobacillus stearothermophilus. This structure supersedes the now removed PDB entry 5pfk. The following page contains interesting information on the relation of 6PFK with [The Glycolytic Enzymes]. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of the allosteric behaviour of phosphofructokinase., Schirmer T, Evans PR, Nature. 1990 Jan 11;343(6254):140-5. PMID:2136935 Page seeded by OCA on Sun May 4 22:42:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:6pfk.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 6pfk |SIZE=350|CAPTION= <scene name='initialview01'>6pfk</scene>, resolution 2.6&Aring;
+The line below this paragraph, containing "STRUCTURE_6pfk", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= PFK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
+-->
-|DOMAIN=
+{{STRUCTURE_6pfk|  PDB=6pfk  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfk OCA], [http://www.ebi.ac.uk/pdbsum/6pfk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6pfk RCSB]</span>
-}}
 '''PHOSPHOFRUCTOKINASE, INHIBITED T-STATE'''
@@ Line 19: / Line 16: @@
 ==About this Structure==
-PFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. This structure supersedes the now removed PDB entry 5PFK. The following page contains interesting information on the relation of 6PFK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFK OCA].
+PFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5pfk 5pfk]. The following page contains interesting information on the relation of 6PFK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFK OCA].
 ==Reference==
@@ Line 30: / Line 27: @@
 [[Category: Evans, P R.]]
 [[Category: Schirmer, T.]]
-[[Category: glycolysis]]
+[[Category: Glycolysis]]
-[[Category: kinase]]
+[[Category: Kinase]]
-[[Category: transferase]]
+[[Category: Transferase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:42:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:43:27 2008''