5nn9: Difference between revisions

Revision as of 22:36, 4 May 2008

REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS

OverviewOverview

The crystal structure of the N9 subtype neuraminidase of influenza virus was refined by simulated annealing and conventional techniques to an R-factor of 0.172 for data in the resolution range 6.0 to 2.2 A. The r.m.s. deviation from ideal values of bond lengths is 0.014 A. The structure is similar to that of N2 subtype neuraminidase both in secondary structure elements and in their connections. The three-dimensional structures of several escape mutants of neuraminidase, selected with antineuraminidase monoclonal antibodies, are also reported. In every case, structural changes associated with the point mutation are confined to the mutation site or to residues that are spatially immediately adjacent to it. The failure of antisera to cross-react between N2 and N9 subtypes may be correlated with the absence of conserved, contiguous surface structures of area 700 A2 or more.

About this StructureAbout this Structure

5NN9 is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.

ReferenceReference

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants., Tulip WR, Varghese JN, Baker AT, van Donkelaar A, Laver WG, Webster RG, Colman PM, J Mol Biol. 1991 Sep 20;221(2):487-97. PMID:1920429 Page seeded by OCA on Sun May 4 22:36:19 2008

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OCA

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 '''REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS'''
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 [[Category: Varghese, J N.]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:36:19 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:41:53 2008''