3c9j: Difference between revisions
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{{STRUCTURE_3c9j| PDB=3c9j | SCENE= }} | |||
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'''The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex''' | '''The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex''' | ||
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==About this Structure== | ==About this Structure== | ||
3C9J is a [[Single protein]] structure | 3C9J is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9J OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Salom, D.]] | [[Category: Salom, D.]] | ||
[[Category: Stouffer, A L.]] | [[Category: Stouffer, A L.]] | ||
[[Category: | [[Category: Ion channel]] | ||
[[Category: | [[Category: M2-amantadine complex]] | ||
[[Category: | [[Category: M2tm]] | ||
[[Category: | [[Category: Membrane protein]] | ||
[[Category: | [[Category: Proton channel]] | ||
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Revision as of 21:29, 4 May 2008
The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex
OverviewOverview
The M2 protein from influenza A virus is a pH-activated proton channel that mediates acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90% (ref. 1). Here we describe the crystal structure of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of the channel-blocking drug amantadine. pH-dependent structural changes occur near a set of conserved His and Trp residues that are involved in proton gating. The drug-binding site is lined by residues that are mutated in amantadine-resistant viruses. Binding of amantadine physically occludes the pore, and might also perturb the pK(a) of the critical His residue. The structure provides a starting point for solving the problem of resistance to M2-channel blockers.
About this StructureAbout this Structure
3C9J is a Single protein structure. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the function and inhibition of an influenza virus proton channel., Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF, Nature. 2008 Jan 31;451(7178):596-9. PMID:18235504 Page seeded by OCA on Sun May 4 21:29:34 2008