2zb0: Difference between revisions

Revision as of 20:06, 4 May 2008

Crystal structure of P38 in complex with biphenyl amide inhibitor

OverviewOverview

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

About this StructureAbout this Structure

2ZB0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306 Page seeded by OCA on Sun May 4 20:06:14 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2zb0.jpg|left|200px]]
- {{Structure
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+You may change the PDB parameter (which sets the PDB file loaded into the applet)
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+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span>
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zb0 OCA], [http://www.ebi.ac.uk/pdbsum/2zb0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2zb0 RCSB]</span>
-}}
 '''Crystal structure of P38 in complex with biphenyl amide inhibitor'''
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 [[Category: Single protein]]
 [[Category: Somers, D O.]]
-[[Category: alternative splicing]]
+[[Category: Alternative splicing]]
-[[Category: atp-binding]]
+[[Category: Atp-binding]]
-[[Category: cytoplasm]]
+[[Category: Cytoplasm]]
-[[Category: map kinase]]
+[[Category: Map kinase]]
-[[Category: nucleotide-binding]]
+[[Category: Nucleotide-binding]]
-[[Category: nucleus]]
+[[Category: Nucleus]]
-[[Category: p38]]
+[[Category: P38]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: serine/threonine protein kinase]]
+[[Category: Serine/threonine protein kinase]]
-[[Category: transferase]]
+[[Category: Transferase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:06:14 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:20:02 2008''