2z6h: Difference between revisions

Revision as of 20:00, 4 May 2008

Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain

OverviewOverview

beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.

About this StructureAbout this Structure

2Z6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222 Page seeded by OCA on Sun May 4 20:00:14 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2z6h.jpg|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_2z6h", creates the "Structure Box" on the page.
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-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00020 ARM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00185 ARM]</span>
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-|RELATEDENTRY=[[2z6g|2Z6G]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6h OCA], [http://www.ebi.ac.uk/pdbsum/2z6h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6h RCSB]</span>
-}}
 '''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain'''
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 [[Category: Xu, W.]]
 [[Category: Zheng, J.]]
-[[Category: activator]]
+[[Category: Activator]]
-[[Category: alternative splicing]]
+[[Category: Alternative splicing]]
-[[Category: beta-catenin]]
+[[Category: Beta-catenin]]
-[[Category: c-terminal domain]]
+[[Category: C-terminal domain]]
-[[Category: cell adhesion]]
+[[Category: Cell adhesion]]
-[[Category: crystal structure]]
+[[Category: Crystal structure]]
-[[Category: cytoplasm]]
+[[Category: Cytoplasm]]
-[[Category: cytoskeleton]]
+[[Category: Cytoskeleton]]
-[[Category: disease mutation]]
+[[Category: Disease mutation]]
-[[Category: nucleus]]
+[[Category: Nucleus]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: polymorphism]]
+[[Category: Polymorphism]]
-[[Category: structural protein]]
+[[Category: Structural protein]]
-[[Category: transcription]]
+[[Category: Transcription]]
-[[Category: transcription regulation]]
+[[Category: Transcription regulation]]
-[[Category: ubl conjugation]]
+[[Category: Ubl conjugation]]
-[[Category: wnt signaling pathway]]
+[[Category: Wnt signaling pathway]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:00:14 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:07 2008''