2vdg: Difference between revisions

Revision as of 18:38, 4 May 2008

BARLEY ALDOSE REDUCTASE 1 COMPLEX WITH BUTANOL

OverviewOverview

In most higher plants a period of desiccation is the terminal event in embryogenesis. Excised barley embryos acquire desiccation tolerance at a precise developmental stage and cDNA clones have been isolated which are temporally linked with desiccation tolerance. One such clone (pG22-69) with a putative gene product of 34 kd displays high structural homology to mammalian genes encoding an NADPH dependent aldose reductase involved in the synthesis of sorbitol. This first aldose reductase gene of plants is expressed constitutively during embryo maturation and is modulated by the plant hormones abscisic acid (ABA) and gibberellic acid (GA). Immunohistochemistry showed that the protein is preferentially expressed in tissues formed at early stages in embryogenesis. Measurements of enzymatic activity indicate that pG22-69 encodes an active aldose reductase. The finding of this reductase activity and the cloning of the corresponding gene supports the existence of a metabolic pathway in plants playing a role in the synthesis of osmolytes like sorbitol. The significance of this work is that genes of related structure and functions are being used in diverse organisms to fulfil stress related biological requirements.

About this StructureAbout this Structure

2VDG is a Single protein structure of sequence from Hordeum vulgare. Full crystallographic information is available from OCA.

ReferenceReference

An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein., Bartels D, Engelhardt K, Roncarati R, Schneider K, Rotter M, Salamini F, EMBO J. 1991 May;10(5):1037-43. PMID:1827067 Page seeded by OCA on Sun May 4 18:38:42 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2vdg.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2vdg |SIZE=350|CAPTION= <scene name='initialview01'>2vdg</scene>, resolution 1.92&Aring;
+The line below this paragraph, containing "STRUCTURE_2vdg", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:1bo+Binding+Site+For+Chain+A'>AC5</scene> and <scene name='pdbsite=AC6:1bo+Binding+Site+For+Chain+A'>AC6</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2vdg|  PDB=2vdg  |  SCENE=  }}
-|RELATEDENTRY=[[2bgs|2BGS]], [[2bgq|2BGQ]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdg OCA], [http://www.ebi.ac.uk/pdbsum/2vdg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vdg RCSB]</span>
-}}
 '''BARLEY ALDOSE REDUCTASE 1 COMPLEX WITH BUTANOL'''
@@ Line 31: / Line 28: @@
 [[Category: Olsen, O.]]
 [[Category: Pedersen, L.]]
-[[Category: akr4c]]
+[[Category: Akr4c]]
-[[Category: aldo-keto reductase]]
+[[Category: Aldo-keto reductase]]
-[[Category: aldose reductase]]
+[[Category: Aldose reductase]]
-[[Category: ligand complex]]
+[[Category: Ligand complex]]
-[[Category: nadp]]
+[[Category: Nadp]]
-[[Category: oxidoreductase]]
+[[Category: Oxidoreductase]]
-[[Category: stress response]]
+[[Category: Stress response]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:38:42 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:16 2008''