2v02: Difference between revisions

Revision as of 17:56, 4 May 2008

RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA

OverviewOverview

Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.

About this StructureAbout this Structure

2V02 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

A structural insight into lead neurotoxicity and calmodulin activation by heavy metals., Kursula P, Majava V, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360 Page seeded by OCA on Sun May 4 17:56:17 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2v02.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2v02 |SIZE=350|CAPTION= <scene name='initialview01'>2v02</scene>, resolution 2.20&Aring;
+The line below this paragraph, containing "STRUCTURE_2v02", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Ba+Binding+Site+For+Chain+A'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2v02|  PDB=2v02  |  SCENE=  }}
-|RELATEDENTRY=[[1aji|1AJI]], [[1cdl|1CDL]], [[1cll|1CLL]], [[1ctr|1CTR]], [[1iwq|1IWQ]], [[1j7o|1J7O]], [[1j7p|1J7P]], [[1k90|1K90]], [[1k93|1K93]], [[1l7z|1L7Z]], [[1lvc|1LVC]], [[1nkf|1NKF]], [[1pk0|1PK0]], [[1s26|1S26]], [[1sk6|1SK6]], [[1sw8|1SW8]], [[1wrz|1WRZ]], [[1xfu|1XFU]], [[1xfv|1XFV]], [[1xfw|1XFW]], [[1xfx|1XFX]], [[1xfy|1XFY]], [[1xfz|1XFZ]], [[1y6w|1Y6W]], [[1yr5|1YR5]], [[1yrt|1YRT]], [[1yru|1YRU]], [[1zot|1ZOT]], [[2be6|2BE6]], [[2f3y|2F3Y]], [[2f3z|2F3Z]], [[2v01|2V01]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v02 OCA], [http://www.ebi.ac.uk/pdbsum/2v02 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v02 RCSB]</span>
-}}
 '''RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA'''
@@ Line 27: / Line 24: @@
 [[Category: Kursula, P.]]
 [[Category: Majava, V.]]
-[[Category: acetylation]]
+[[Category: Acetylation]]
-[[Category: calcium]]
+[[Category: Calcium]]
-[[Category: metal-binding protein]]
+[[Category: Metal-binding protein]]
-[[Category: methylation]]
+[[Category: Methylation]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: ubl conjugation]]
+[[Category: Ubl conjugation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:56:17 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:51 2008''